THE Simpsons fans have been left stunned as the show’s iconic twins Patty and Selma Bouvier have undergone a shock ‘Ozempic transformation’ on the show.
The long-running animated sitcom has taken a look at the weight-loss jab which has taken the world by storm with both Patty and Selma ditching a tonne of weight by using a jab.
They aren’t the only ones who will be sporting a slimmed down appearance in the latest episode of the programme as Comic Book Guy, famed for wearing a T-shirt too small for his bulging belly, will also show off a new look thanks to the weight-loss apparatus.
In an episode aired last night, entitled The Last Man Expanding, fans saw how all three characters had managed to ditch the fat.
As the new craze hit Springfield, the characters were all left attempting to lose the pounds through their version of the drug, called “Othinquic”.
It left chain-smoking sisters Patty and Selma looking unrecognisable as they were left as thing as their other sister, Marge.
Read More on The Simpsons
But despite already being petite herself, Marge was also left tempted to use the Ozempic-style drug after seeing how many of her neighbours, and family members, had transformed their bodies as a result.
One of the biggest transformations was the hugely overweight Comic Book Guy who looked unrecognisable after devouring “family-sized Othinquic”.
But some fans have been left unhappy by the decision for The Simpsons to go down the weight-loss route – particularly with Patty and Selma.
Writing online, one fan posted on X: “Can’t believe what Ozempic is doing to our beautiful queens.”
Another insisted: “They were already perfect.”
As a third shared: “I’m surprised Patty and Selma went in for it too…”
However, their slimmed down physique’s are unlikely to stay for future episodes with most episode of The Simpsons reverting back to its original plot lines with each episode in order to keep it set within a linear universe.
New episodes of The Simpsons stream exclusively on Disney+ in the UK after leaving Channel 4 in a shock move for the first time in 20 years in January.
Fans of the programme have tuned in at 6:30pm for years to get their regular Simpsons fix – but were left disappointed when it meant under a new UK deal, Channel 4 would no longer be screening the show.
However, terrestrial television will still get some Simpsons episodes, albeit a few series behind.
In January, E4 became the only home of the show on linear TV with episodes from season 32 airing on the channel.
These episodes will then be made available to stream on Channel 4’s online platform for a very limited time shortly after airing before being ultimately retained exclusively by Disney+.
The Simpsons ‘predictions’ over the years which came true

Fans have noticed that The Simpsons has had a tendency to “predict the future
1992 – SUPER BOWL: In an episode titled Lisa the Greek, the brainiest Simpson tells dad Homer that the Washington Redskins will win if she still loves her dad, and the Buffalo Bills will win if she no longer does. In the end, Washington wins. The episode aired a few days before the actual Super Bowl, correctly depicting the outcome.
1995 – FACETIME: The episode Lisa’s Wedding predicted the technology down to the year it was announced – with a future scene set in 2010 showing a video call.
1998 – DISNEY CONGLOMERATE: In the episode When You Dish Upon a Star, Homer makes a comment about 20th Century Fox becoming a part of Disney Corporation. This became a reality 19 years later, in 2017.
2000 – DONALD TRUMP PRESIDENCY: The episode Bart to the Future features Lisa as US President. She’s seen talking to her staff about the “budget crunch” she inherited from former President Trump. Of course, businessman Donald Trump actually would become President 15 years after the episode aired.
2005 – CANADA’S MARIJUANA LEGALISATION: In Midnight Rx, Homer, Ned, Apu, and Grampa Simpson visit Canada and find out that Marijuana is legal. This legalisation would later become a reality in 2018.
2008 – E-VOTING ISSUE: Treehouse of Horror XIX sees Homer attempting to vote for Barack Obama on an e-voting machine, but the machine instead registered the vote for election rival John McCain. Four years later, in the 2012 election, an issue with vote swapping occurring at electronic voting machines.
2010 – OLYMPICS PREDICTION: In Boy Meets Curl, Homer and Marge win Gold against Sweden who claims silver at the Olympics. Eight years later, the prediction proved accurate with Sweden’s curling team winning silver against the US Men’s team at the 2018 Winter Olympics.
2010 – NOBEL PRIZES: Milhouse predicts in Elementary School Musical that Finnish MIT economics professor, Bengt Holmstrom, and Dutch chemist, Ben Feringa, would win Nobel Prizes in their respective areas. This would ultimately come true in 2016.
2012 – LADY GAGA/SUPER BOWL: In the episode Lisa Goes Gaga, Lady Gaga flies over the audience while attached to cables. Five years later, the pop star performed at at the Halftime show and descended from the stadium’s roof as her massive entrance.
2024: DONALD TRUMP ASSASSINATION ATTEMPT: Following Donald Trump almost being assassinated in July 2024, Channel 4 pulled a repeat of an episode that originally aired in the 90s. The episode featured an active gunman could be seen on the roof of a building as a public gathering took place, similar to the staging at Trump’s rallies.